To create a realistic car animation in Blender, start with a detailed car model and rig it for wheel rotation, suspension, and chassis dynamics. Design an environment suited to the scene, such as urban streets, forests, or deserts, with realistic textures and materials. Animate the car with natural movements, adding effects like tire deformation and dust for realism. Use HDRI lighting and dynamic camera angles to enhance the visuals, and render in Cycles with optimized settings for smooth motion blur. Finalize with post-processing for color grading and visual effects to complete the animation.